Manuela Ranno was born in Trapani, Italy.
After completing her studies in foreign languages, she obtained a diploma in opera singing in 2011 and subsequently a specialist degree in Renaissance and Baroque singing under the guidance of Sonia Prina. Afterward, she concluded with a high score her studies in orchestral conducting, under the guidance of Maestro C. Caruso, at the V. Bellini Conservatory in Palermo.
For some years she followed Maestro Matteo Beltrami as Assistant.
For the 2018/2019 season, she held the appointment of Music Director of the Francesco Cilea Philharmonic Orchestra of Reggio Calabria for the Rhegium Opera Musica Festival, debuting the opera «Turandot».
In August 2018 she collaborated with the Tones on the Stones Festival, conducting music by Rossini in a show on the occasion of the composer's 150th anniversary. In the same year, she made her debut in F. Mendelssohn's Symphony No. 4 at the Coccia Theatre in Novara while in Palermo she performed with «Symphony No. 9" by A. Dvorak, «Stabat Mater» and «La serva padrona» by Pergolesi.
In August 2019 she also conducted titles such as «La Traviata», «Il Barbiere di Siviglia», lyric-symphonic concerts and prepared the orchestra for the world premiere of A. Galanti's «Via Crucis» at the F. Cilea Theatre in Reggio Calabria.
Her next engagements include the debut at Graz Opera Theatre in season 2021/22.